Physical arguments stemming from the theory of black-hole thermodynamics are used to put constraints on the dynamics of closed-string tachyon condensation in Scherk–Schwarz compactifications. A geometrical interpretation of the tachyon condensation involves an effective capping of a noncontractible cycle, thus removing the very topology that supports the tachyons. A semiclassical regime is identified in which the matching between the tachyon condensation and the black-hole instability flow is possible. We formulate a generalized correspondence principle and illustrate it in several different circumstances: (...) an Euclidean interpretation of the transition from strings to black holes across the Hagedorn temperature and instabilities in the brane-antibrane system. (shrink)

The current article aims to provide an up-to-date synopsis of available techniques to study affect dynamics using intensive longitudinal data. We do so by introducing the following eight dichotomies that help elucidate what kind of data one has, what process aspects are of interest, and what research questions are being considered: single- versus multiple-person data; univariate versus multivariate models; stationary versus nonstationary models; linear versus nonlinear models; discrete time versus continuous time models; discrete versus continuous variables; time versus frequency domain; (...) and modeling the process versus computing descriptives. In addition, we discuss what we believe to be the most urging future challenges regarding the modeling of affect dynamics. (shrink)

The combination of breeding for increased production and the intensification of housing conditions have resulted in increased occurrence of behavioral, physiological, and immunological disorders. These disorders affect health and welfare of production animals negatively. For future livestock systems, it is important to consider how to manage and breed production animals. In this paper, we will focus on selective breeding of laying hens. Selective breeding should not only be defined in terms of production, but should also include traits related to animal (...) health and welfare. For this we like to introduce the concept of robustness. The concept of robustness includes individual traits of an animal that are relevant for health and welfare. Improving robustness by selective breeding will increase (or restore) the ability of animals to interact successfully with the environment and thereby to make them more able to adapt to an appropriate husbandry system. Application of robustness into a breeding goal will result in animals with improved health and welfare without affecting their integrity. Therefore, in order to be ethically acceptable, selective breeding in animal production should accept robustness as a breeding goal. (shrink)

Children, because of age-related reasons, are a vulnerable population, and protecting their health is a social, scientific and emotional priority. The increased susceptibility of children and fetuses to environmental agents has been widely discussed by the scientific community. Children may experience different levels of chemical exposure than adults, and their sensitivity to chemical toxicities may be increased or decreased in comparison with adults. Such considerations also apply to unborn and newborn children. Therefore, research on children is necessary in both clinical (...) and environmental fields, to provide age-specific relevant data regarding the efficacy and safety of medical treatments, and regarding the assessment of risk from unintended environmental exposure. In this context, the stakeholders are many, including children and their parents, physicians and public health researchers, and the society as a whole, with its ethical, regulatory, administrative and political components. The important ethical issues are information of participants and consent to participate. Follow-up and protection of data should be discussed in the context of biobanks, where children obtain individual rights when they become adults. It is important to realise that there are highly variable practices within European countries, which may have, in the past, led to differences in practical aspects of research in children. A number of recommendations are provided for research with children and environmental health. Environmental research with children should be scientifically justified, with sound research questions and valid study protocols of sufficient statistical power, ensuring the autonomy of the child and his/her family at the time of the study and later in life, if data and samples are used for follow-up studies. When children are enrolled, we recommend a consent dyad, including parental informed consent and the child’s assent and/or informed consent from older minors. For evaluation of the studies including children, a paediatrician should always be involved in the research ethics committee. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

R. J. O'Connell’s latest book has all the sterling literary qualities of its predecessors, St. Augustine’s Early Theory of Man and St. Augustine’s Confessions: The Odyssey of the Soul. The task in the present case was fraught with new and graver perils; for, although considerations on art abound in Augustine, the subject never receives the full-blown treatment to which modern aesthetic theory has accustomed us. The one possible exception to this rule is the De musica, but even it deals with (...) music as a science rather than as an art and does little to alter the perspective established in the other dialogues. The bulk of the essay traces the evolution of Augustine’s theory of art through the early dialogues, the Confessions, and, in less detailed fashion, the works of his mature period. (shrink)

This slender volume contains a rapid sketch of the development of the notions of conscience and synderesis in medieval thought. Its timeliness is vouched for by the fact that conscience, to which appeal is so often made today, has not been thus far a major theme of modern philosophy. Much of the book's information is quarried from O. Lottin's classic study, Psychologie et morale aux XIIe et XIIIe siècles, whose findings have been restated in terms that are meant to be (...) "psychologically" accessible to the modern mind. The Preface calls attention to the undue neglect of medieval philosophy on the part of twentieth-century thinkers, many of whom still cling to the view that philosophy died with Aristotle and came to life again only with Descartes. It also laments the "party spirit" that once tended to characterize the Neo-Scholastic movement, as well as the one-sided emphasis on Thomas Aquinas within that movement. Potts has accordingly sought to broaden the scope of his inquiry by taking into consideration five widely different authors through whose writings one begins to glimpse the subtlety of the medieval teaching on this important topic: Jerome, who introduced the word "synderesis" into the debate ; Peter Lombard, whose Sentences provided the mandatory point of departure for all subsequent discussions of the subject; Philip the Chancellor, the author of the first medieval treatise on conscience; and, finally, Bonaventure and Thomas Aquinas, two of the writers who contributed most significantly to the further elaboration of the doctrine. By the author's own admission, numerous other theologians, whose names are listed in an appendix, could have been included in the roster or substituted for the ones that are included. The book is divided into two even parts, the first of which presents an analysis of the thought of each of the five theologians mentioned, and the second a selection of representative texts from their works. For the convenience of teachers, a "programme for a medieval-philosophy course on conscience" has been added under Appendix 2. (shrink)

The author of these two complementary essays, neither of which he lived to see in final published form, was one of the most distinguished Jesuit scholars of his generation. Alexander Kojève, whose seminar on Hegel he attended from 1934 to 1939, once remarked that he could have been "easily and by far" France's best Marxist theorist if he had so desired. Partly because of the topical nature of his works, but perhaps even more because of his philosophic depth, he was (...) never read as widely outside of France as are his illustrious confrères, Henri de Lubac and Jean Daniélou. Of the one hundred and twenty-odd items listed in his bibliography only three articles have thus far been translated into English. Yet this impressive literary production could well become one of the landmarks of contemporary French Catholicism. (shrink)

Jung’s Crisis is an ambitious book written from the dogmatic perspective of a firm believer in the redeeming virtue of phenomenology. Like the works of Alfred Schutz and Aron Gurvitsch, on which it often relies, it combines a commitment to phenomenology with a lively interest in social theory. Above all, it claims to be the first treatise systematically to apply the relatively new phenomenological paradigm to the realm of politics. Its undergirding thesis is that philosophical phenomenology is destined to supersede (...) all previous as well as all currently dominant modes of political discourse. Phenomenology is understood throughout not simply as a method, as it is for example in Heidegger’s Being and Time, section 7, but in the Husserlian sense of a complete and rigorous science capable of securing universal assent, of synthesizing theory and practice, and of overcoming the numerous dichotomies that have traditionally plagued the house of philosophy. (shrink)

O'Donovan's gracefully written book is a late but welcome addition to an already large body of literature spawned directly or indirectly by A. Nygren's epoch-making Agape and Eros, the first installment of which appeared in 1930. Most of the ground that it covers is aptly described as a battlefield "on which the smoke still hangs heavy". Interestingly enough, Augustine is the first Latin writer to make extensive use of the expression amor sui or "self-love," which occurs some one-hundred and fifty (...) times throughout his voluminous corpus. Although once accepted virtually without question, his views on this crucial subject have not met with universal approval in our century. Nygren was convinced that Augustine had dealt a lethal blow to the self-denying agape of the Gospel by synthesizing it with the essentially self-regarding eros of Platonic philosophy. Others have since rallied to Augustine's defense, but without always doing full justice to the complexity of his thought. Hence the need for a global assessment of the problem based on a careful scrutiny of the evidence at hand. (shrink)

This book explores the universe and its subsystems from the three lenses of evolutionary (diversifying), developmental (converging), and complex (adaptive) processes at all scales. It draws from prolific experts within the academic disciplines of complexity science, physical science, information and computer science, theoretical and evo-devo biology, cosmology, astrobiology, evolutionary theory, developmental theory, and philosophy. The chapters come from a Satellite Meeting, "Evolution, Development and Complexity" (EDC) hosted at the Conference on Complex Systems, in Cancun, 2017. The contributions will be peer-reviewed (...) and contributors from outside the conference will be invited to submit chapters to ensure full coverage of the topics. This book explores many issues within the field of EDC such as the interaction of evolutionary stochasticity and developmental determinism in biological systems and what they might teach us about these twin processes in other complex systems. This text will appeal to students and researchers within the complex systems and EDC fields.. (shrink)

The scientific study of consciousness emerged as an organized field of research only a few decades ago. As empirical results have begun to enhance our understanding of consciousness, it is important to find out whether other factors, such as funding for consciousness research and status of consciousness scientists, provide a suitable environment for the field to grow and develop sustainably. We conducted an online survey on people’s views regarding various aspects of the scientific study of consciousness as a field of (...) research. 249 participants completed the survey, among which 80% were in academia, and around 40% were experts in consciousness research. Topics covered include the progress made by the field, funding for consciousness research, job opportunities for consciousness researchers, and the scientific rigor of the work done by researchers in the field. The majority of respondents (78%) indicated that scientific research on consciousness has been making progress. However, most participants perceived obtaining funding and getting a job in the field of consciousness research as more difficult than in other subfields of neuroscience. Overall, work done in consciousness research was perceived to be less rigorous than other neuroscience subfields, but this perceived lack of rigor was not related to the perceived difficulty in finding jobs and obtaining funding. Lastly, we found that, overall, the global workspace theory was perceived to be the most promising (around 28%), while most non-expert researchers (around 22% of non-experts) found the integrated information theory (IIT) most promising. We believe the survey results provide an interesting picture of current opinions from scientists and researchers about the progresses made and the challenges faced by consciousness research as an independent field. They will inspire collective reflection on the future directions regarding funding and job opportunities for the field. (shrink)

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)